Sicilian Vampire

James Caan

Professor Bernard Issaacs

Daryl Hannah

Carmelina Trafficante

Paul Sorvino

Jimmy Scambino

Robert Loggia

Santino Trafficante Sr.

Armand Assante

Vince

Robert Davi

Big Sal - The Don

Michael Paré

Sammy

Eric Roberts

Detective Louis Marshall

Daniel Baldwin

Vito

Tony Nardi

Little Anthony (Sonny's wise guy)

Frank D'Angelo

Santino Trafficante Jr. (Santo)

Phil Esposito

Philly (friend of Santo's at Don Giovanni's)

Art Hindle

Detective Domenic Durpray

Ellen Dubin

Vince's Mistress